Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy

•The TRPV1 agonist, capsaicin, increases paroxysmal activity in MDA model.•The antagonist capsazepine protects from epileptiform discharges.•Pretreatment with capsaicin impairs antiepileptic action of WIN.•Co-administration with capsazepine enhances WIN protection from epileptic events.•CB and TRPV1 cross-talk in the modulation of hyperexcitability in experimental TLE.