Abstract 387: Bioengineering L-605 Cobalt Chromium Cardiovascular Stent Biomaterial With Plasma Activated Coating, for Proactive Biocompatibility

Introduction: Cobalt Chromium alloy L605 is an underlying biomaterial in new generation drug eluting stents (DES) and bare metal stents (BMS). Suboptimal biocompatibility of stents clinically manifest as thrombosis and restenosis. We optimized a plasma coating technology to activate an alloy L605 surface for enhanced biofunctionalization. Objective: Alloy L605 flat metal surface modified with plasma activated coating (PAC), covalently binds tropoelastin (TE) in its bioactive state. In vitro studies were conducted to assess biocompatibility of modified PAC biomaterial compared to the bare metal alloy L605. Methods and Results: The initial water contact angle (Kruss contact angle analyser, DS10) of PAC was 44.40±3.40 and correlating surface energy computed with the Owens-Wendt-Rabel-Strom kinetic model was 62.35±2.4 mJ/m2. Thrombogenicity studies with heparinised whole blood (0.5 U/mL, 370C), in a modified chandler loop showed significantly less clot formation at 60 mins for PAC, PAC+TE Vs. L605 surfaces; 2...