GlyT1 inhibitors promote dopaminergic striatal sprouting

2. GlyT1 inhibitor (ACPPB) treatment enhanced dopaminergic reinnervation of dorsal striatum Reinnervation of the dorsal striatum was examined at 7 weeks post-lesion in cryosections stained for the dopamine transporter (DAT, A, arrows indicate dorsal-most fibers). Structures resembling axonal growth cones were found in the dorsal striatum (B). Axon density was quantified as area coverage normalized to that of the unlesioned hemisphere in 4 dorsoventrally arranged regions as indicated (1-4). Axon density in the more medial and ventral striatal regions (3 and 4) was about two-fold higher in ACPPB-treated mice (C).