LOWER AIRWAY INFLAMMATION AND HYPERRESPONSIVENESS IN ALLERGIC AND NON-ALLERGIC RHINITIS
European Respiratory Journal(2011)
摘要
Background: Remarkable relationship exists between upper and lower airways, but lack of large-sample study on total airway inflammation and hyperresponsiveness in allergic and non-allergic rhinitis.
Objectives: To investigate lower airway inflammation and hyperresponsiveness in allergic and non-allergic rhinitis without asthma.
Methods: We enrolled 166 subjects with allergic rhinitis (AR), 122 with non-allergic rhinitis (NAR) and 143 healthy volunteers (control). Nasal-lavage, induced sputum, lower airway fractional exhaled nitric oxide (FeNO), methacholine bronchial provocation tests and allergen skin prick test were performed.
Results: AR group showed high nasal-lavage eosinophils count [6.90 (22.40)/×200]. Sputum eosinophil was 1.50% (5.38%) in AR, higher than NAR [0.25% (1.00%)] and control [0% (0.50%), P 3%) showed statistical difference ( P <0.05) in nasal eosinophils [15.65 (41.60)/×200 vs.2.05 (14.45)/×200], FeNO [31.61±21.52ppb vs.19.96±14.34ppb], mild and borderline BHR count [13 (22.03%) vs.7 (6.54%)] when compared with 107 cases without sputum eosinophils increased.
Conclusions: Allergic rhinitis presents obvious upper/lower airway inflammation and BHR when compared with non-allergic rhinitis. High sputum eosinophil level in allergic rhinitis is closely correlated with nasal eosinophils, FeNO and BHR.
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关键词
Allergic rhinitis,Non-allergic rhinitis,Airway inflammation,Airway hyper-responsiveness
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