Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression: Disease and staging biomarkers and new drug targets.

Carine Coneglian de Farias,Michael Maes,Kamila Landucci Bonifácio,Chiara Cristina Bortolasci,André de Souza Nogueira,Francis Fregonesi Brinholi,Andressa Keiko Matsumoto,Matheus Amarante do Nascimento,Lúcio Baena de Melo,Suzana Lucy Nixdorf,Edson Lopes Lavado,Estefânia Gastaldello Moreira,Décio Sabbatini Barbosa

Neuroscience Letters（2016）

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摘要

•Plasma MDA may serve as a highly sensitive and specific disease biomarker of PD.•Plasma LOOH and SOD expression may serve as staging biomarkers of PD.•New treatments for PD should target lipid peroxidation and lowered antioxidant defenses.

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关键词

Parkinson disease,Oxidative stress,Antioxidants,Malondialdehyde,Staging

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