Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

Tamjeed Saleh,Wojciech Jankowski,Ganapathy Sriram,Paolo Rossi,Shreyas Shah,Ki-Bum Lee,Lissette Alicia Cruz,Alexis J Rodriguez,Raymond B Birge,Charalampos G Kalodimos

NATURE CHEMICAL BIOLOGY（2015）

引用 26|浏览15

暂无评分

摘要

Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to stimulate cellular migration.

查看译文

关键词

Bacteria,Genetics,Membranes,Target identification,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要