Differential immunomodulatory effects of Lactobacillus rhamnosus DR20, Lactobacillus fermentum CECT 5716 and Bifidobacterium animalis subsp. lactis on monocyte-derived dendritic cells
Journal of Functional Foods(2016)
摘要
•We studied six probiotics commonly used in functional foods, and with a known effect on the maturation of human MoDCs.•L. rhamnosus induced the maturation on MoDCs, which primed the differentiation of Th1 cells.•L. fermentum induced a specific response on MAPK, NF-κB, AP-1 and STAT3 related genes.•B. lactis had no effect on the maturation state of MoDCs and decreases the mRNA expression levels of CXCL10.
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关键词
Dendritic cell,Probiotic,Maturation,Toll-like receptor
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