Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice

Soumeya Abed,Alisa Tubsuwan,Porntip Chaichompoo,In-Hyun Park, Alice Pailleret,Aïssa Benyoucef,Lucie Tosca,Edouard de Dreuzy,Anais Paulard, Marine Granger-Locatelli,Francis Relouzat,Stéphane Prost,Gérard Tachdjian,Suthat Fucharoen,George Q. Daley,Emmanuel Payen,Stany Chrétien,Philippe Leboulch,Leila Maouche-Chretien

HAEMATOLOGICA（2015）

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摘要

The use of iPSCs to generate hematopoietic stem/progenitor cells (HSPC) is of considerable therapeutic interest, as allogeneic HSPC transplantation is limited by the lack of compatible donors, a high risk of engraftment failure and GVHD. Efficacy and safety assessments are required and non-human

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关键词

Nonhuman primate,Induced pluripotent stem cells,Engraftment of cy-iPSC-derived hematopoietic cells

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