Pd/Cu-Catalyzed Cascade C(sp3)–H Arylation and Intramolecular C–N Coupling: A One-Pot Synthesis of 3,4-2H-Quinolinone Skeletons

In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C­(sp3)–H arylation of amides and intramolecular C–N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2H-quinolinone with good regioselectivity of C–H arylation and C–N coupling from C–I and C–X bonds from readily available starting materials.