Activation of IGF/IGF-IR signaling pathway fails to induce epithelial-mesenchymal transition in pancreatic cancer cells.

E P Kopantzev,M R Kopantseva, E V Grankina,A Mikaelyan,V I Egorov,E D Sverdlov

Pancreatology（2019）

引用 11|浏览26

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摘要

Our results demonstrate that IGF-I does not function as an effective inductor of EMT in pancreatic cancer cell lines and that stimulation of IGF-I/IGF-IR signaling pathway does not lead to EMT associated changes in cell differentiation.

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关键词

Pancreatic ductal adenocarcinoma,Tumor microenvironment,Insulin-like growth factor-I,Signal transduction,Epithelial-mesenchymal transition

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