Synthesis of (E)-α,β-unsaturated carboxylic esters derivatives from cyanoacetic acid via promiscuous enzyme-promoted cascade esterification/Knoevenagel reaction.

•The synthesis of (E)-α,β-unsaturated carboxylic esters via enzymatic cascade.•Simple experimental procedure starting from acetal and cyanoacetic acid.•Substantial influence of enzyme on the reaction course.•Good correlation between solvent polarity and reaction yield.•Recycling of multi-promiscuous enzyme without loss of activity.