CATIONIC AND SECRETORY RESPONSE OF PERIFUSED RAT PANCREATIC ISLETS TO INCREMENTAL INCREASE AND FALL IN D-GLUCOSE CONCENTRATION

We have monitored the time course of the cationic and secretory response of rat pancreatic islets at incremental rise and fall in D-glucose concentration between 7.0 and 9.0 mM in a perifusion device. Under these close-to-physiological conditions, the hexose caused changes in Rb-86 and Ca-45 outflow, as well as insulin output, comparable to but less pronounced than that obtained in response to more substantial and rapid variations in D-glucose concentration. Med Sci Res 27:131-133 (C) 1999 Lippincott Williams & Wilkins.