Recording of Neural Activity with Modulation of Photolysis of Caged Compounds using Microelectrode Arrays in Rats with Seizures.

Objective: In this paper, a new method was established to monitor multichannel neural activity with microelectrode arrays (MEAs) under modulation of caged compounds in a rat model of seizures. Methods: The 16-channel MEAs were fabricated and implanted into the hippocampus of normal rats and epileptic rats for neural spike and local field potential (LFP) recording. Using optical fibers with drug de...