Muscle weakness in a S. pneumoniae sepsis mouse model

Annals of translational medicine, Volume 7, Issue 1, 2019, Pages 9

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Keywords:
Intensive care unit-acquired weakness (ICU-AW)animal modelcritical illness myopathy (CIM)critical illness polyneuropathy (CIP)grip strengthMore(1+)

Abstract:

diaphragm weakness, but no limb weakness was found in the mouse model in which severe illness was induced. This does not reflect the full clinical picture of ICU-AW as seen in humans and as such this model did not fulfill our predefined requirements. However, this model may be used to study inflammation induced diaphragmatic weakness.

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