Hyperglycemia aggravates spinal cord injury through endoplasmic reticulum stress mediated neuronal apoptosis, gliosis and activation.

Zhirong Chen,Haohui Guo,Zhidong Lu,Kening Sun,Qunhua Jin

Biomedicine & Pharmacotherapy（2019）

引用 35|浏览13

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摘要

•ER stress was aggravated in hyperglycemic rats after SCI.•ER stress inhibition alleviated neuronal apoptosis and BSCB permeability.•ER stress inhibition showed little influence on glial activation and inflammation.

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关键词

Hyperglycemia,Spinal cord injury (SCI),Endoplasmic reticulum (ER) stress,Neuronal apoptosis,Glial proliferation

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