Chitosan hydrogel containing amelogenin-derived peptide: Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions.

•Controlling pathogenic bacteria as well as promoting re-mineralization are necessary for caries prevention.•A novel, dual-action hydrogel containing remineralizing peptide and antibacterial chitosan.•Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions.•CS-QP5 hydrogel shows promise for dual-action caries control in the clinic.