Gene mutational analysis in a cohort of Chinese children with unexplained epilepsy: Identification of a new KCND3 phenotype and novel genes causing Dravet syndrome.

•The significant utility of NGS panel in the genetic diagnosis of pediatric epilepsy.•KCND3 pathogenic variants might be responsible for a wider phenotypic spectrum, including childhood epileptic encephalopathy.•GRIN1 and HCN1 are candidate genes for Dravet and Dravet-like phenotypes.