Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells.

Rone Aparecido De Grandis,Patrick Wellington da Silva Dos Santos,Katia Mara de Oliveira, Ana Rita Tomazela Machado,Alexandre Ferro Aissa,Alzir Azevedo Batista,Lusânia Maria Greggi Antunes,Fernando Rogério Pavan

Bioorganic Chemistry（2019）

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摘要

•A series of novel ruthenium complexes containing lawsone were synthesized.•The complexes showed potent anticancer activity against several tumor cells.•Complex (4) exhibited remarkable anticancer activity against prostate tumor spheroids.•Complex (4) inhibits DU-145 cell adhesion and migration potential.•Complex (4) induced DU-145 cell apoptosis through elevated intracellular ROS.

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关键词

Cancer,1,4-naphthoquinone,3D-cell culture,ROS,Apoptosis,BAX/BCL-2

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