Prevalence of predicted resistance to doravirine in HIV-1-positive patients after exposure to non-nucleoside reverse transcriptase inhibitors

Gaetana Sterrantino,Vanni Borghi,Anna Paola Callegaro,Bianca Bruzzone,Francesco Saladini,Franco Maggiolo,Gaetano Maffongelli,Massimo Andreoni, Michele De Gennaro,Nicola Gianotti,Patrizia Bagnarelli,Alessandra Vergori,Andrea Antinori,Maurizio Zazzi,Mauro Zaccarelli

International Journal of Antimicrobial Agents（2019）

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摘要

•Doravirine (DOR) resistance is uncommon among non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced patients.•Complete DOR resistance in NNRTI-experienced patients is mainly related to Y188L mutation.•Previous efavirenz and etravirine use are associated with detection of DOR resistance.•Previous rilpivirine use is associated with a lower probability of DOR resistance.

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关键词

HIV-1,Antiretroviral therapy,Doravirine,Predicted resistance,NNRTI,Treatment-experienced subjects

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