Ischemic cardiomyopathy affects the thioredoxin system in the human myocardium.

Stephan Neidhardt,Jens Garbade,Fabian Emrich,Kristin Klaeske,Michael A Borger,Sven Lehmann,Khalil Jawad,Maja-Theresa Dieterlen

Journal of Cardiac Failure（2019）

引用 16|浏览24

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摘要

The Trx system was impaired in ICM but not in DCM. ITCH appeared to be responsible for the downregulation of the Trx system. ROS-induced mitochondrial instability appeared to play a role in DCM.

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关键词

Heart failure,thioredoxin,cardiomyopathy,ITCH,TXNIP,E3 ligases

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