A sputum 6 gene signature predicts future exacerbations of poorly controlled asthma.

Michael Fricker,Peter G Gibson,Heather Powell,Jodie L Simpson,Ian A Yang,John W Upham,Paul N Reynolds,Sandra Hodge,Alan L James,Christine Jenkins,Matthew J Peters,Guy B Marks,Melissa Baraket,Katherine J Baines

Journal of Allergy and Clinical Immunology（2019）

引用 52|浏览69

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摘要

We demonstrate that a sputum gene signature can predict future exacerbation phenotypes of asthma, with greatest biomarker performance in identifying those who would experience frequent severe exacerbations. AZM therapy did not modify 6GS expression or biomarker performance, suggesting the therapeutic action of AZM is independent of 6GS-related inflammatory pathways.

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关键词

Asthma,sputum,biomarker,inflammation,exacerbation,macrolide,azithromycin,eosinophil,gene signature,clinical trial

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