γ-Tocotrienol inhibits oxidative phosphorylation and triggers apoptosis by inhibiting mitochondrial complex I subunit NDUFB8 and complex II subunit SDHB.

HaiXia Wang,JunTao Luo,WenXia Tian,WenQing Yan,Sheng Ge,YaHui Zhang,WenGuang Sun

Toxicology（2019）

引用 20|浏览9

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摘要

•γ-T3 inhibits OXPHOS and triggers the production of ROS in cancer cells.•γ-T3 upregulates the glycolytic capacity in cells, but does not compensate for cellular ATP generation in cells.•γ-T3 specifically decreases the levels of NDUFB8 (a subunit of complex I) and SDHB (a subunit of complex II).

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关键词

γ-Tocotrienol,α-Tocopherol,OXPHOS,ROS,ETC,Δ ψ m,TCA,NADH,SDH,CI, II, III, IV, and V,FCCP,DCFH-DA,OCR,ECAR

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