Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions.

Akira Kanda,Kenji Kondo,Naoki Hosaka,Yoshiki Kobayashi,Dan Van Bui,Yasutaka Yun,Kensuke Suzuki,Shunsuke Sawada,Mikiya Asako,Akihiko Nakamura,Koichi Tomoda,Yoshiko Sakata,Koji Tsuta,David Dombrowicz,Hideyuki Kawauchi,Shigeharu Fujieda,Hiroshi Iwai

Medical sciences (Basel, Switzerland)（2019）

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摘要

This study supports the previously unsuspected contribution of eosinophils to CRS development in the murine model and suggests that murine-activated eosinophilic splenocytes contribute to the development of hyposmia due to more mucosal inflammation than physical airway obstruction and epithelial layer injury with convex lesions.

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关键词

allergic rhinitis,chronic rhino sinusitis,eosinophil,hyposmia,nasal poly

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