Non-inflammatory emphysema induced by NO 2 chronic exposure and intervention with demethylation 5-Azacytidine.

This non-inflammatory rat emphysema model (induced by chronic NO exposure with global DNA hypomethylation and demethylation therapy with 5-Azacytidine) effectively improved emphysema by alleviating the decline of lung function and hypoxia, and slightly reinforced immune function. These results indicate the therapeutic potential of demethylation agents for the prevention and treatment of emphysema induced by the air pollutant NO.