Demethylation of the hypoxia induction factor 1 binding site of GPX3 at excess blood ammonia in propionic acidemia.

C B Item, A Schanzer,T Metz,S Greber-Platzer,J Lischka

Clinical Biochemistry（2019）

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摘要

•Demethylated status of HIF-1α binding site in Gpx3•Demethylation tendency at Hyperammonemia•Putative early marker for an increased radical production

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关键词

Propionic acidemia,Hypoxia-inducible factor-1α,Gluthatione peroxidase 3,DNA methylation,Newborn

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