Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
Biochemical Pharmacology（2019）
摘要
SphK1 expression and/or activation are impaired in hypoxic RAFLS, leading to reduced autocrine S1PR signalling/chemokine loop. (↓: decrease, ↑: increase).
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关键词
Rheumatoid arthritis,Fibroblast-like synoviocytes,Sphingosine-1-phosphate,Sphingosine kinases,Chemokines
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