Alphavirus-vectored hemagglutinin subunit vaccine provides partial protection against heterologous challenge in pigs.

Eugenio J Abente,Daniela S Rajao,Phillip C Gauger,Amy L Vincent

Vaccine（2019）

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摘要

•Monovalent alphavirus-vectored HA vaccines protect against virus with matched HA.•Alphavirus-vectored HA vaccines partially protect against virus with mismatched HA.•Bivalent alphavirus vaccine induced antibody against both HA and was protective.

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关键词

Influenza,Replicon particle,Alphavirus,Subunit vaccine

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