Genome-wide colocalization of RNA-DNA interactions and fusion RNA pairs

Zhangming Yan
Zhangming Yan
Norman Huang
Norman Huang
Weixin Wu
Weixin Wu
Yiqun Jiang
Yiqun Jiang
Jingyao Chen
Jingyao Chen
Xuerui Huang
Xuerui Huang
Xingzhao Wen
Xingzhao Wen
Qiushi Jin
Qiushi Jin

Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Issue 8, 2019, Pages 201819788-3337.

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Keywords:
RNA-poise modelRNA–DNA interactionsfusion transcripts

Abstract:

Fusion transcripts are used as biomarkers in companion diagnoses. Although more than 15,000 fusion RNAs have been identified from diverse cancer types, few common features have been reported. Here, we compared 16,410 fusion transcripts detected in cancer (from a published cohort of 9,966 tumor samples of 33 cancer types) with genome-wide ...More

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