The role of the genetic variants IRX3 rs3751723 and FTO rs9939609 in the obesity phenotypes of children and adolescents.

Pâmela Ferreira Todendi,Andreia Rosane de Moura Valim,Elisa Klinger,Cézane Priscila Reuter,Susana Molina,J Alfredo Martínez,Marilu Fiegenbaum

Obesity Research & Clinical Practice（2019）

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摘要

•It is speculated that the FTO gene are functionally connected with the regulation of the expression of IRX3.•IRX3 rs3751723 was associated with obesity and BF%.•FTO rs9939609 was associated with a higher BMI Z-Score, obesity and WC.•No interaction between IRX3 rs3751723 and FTO rs9939609 was found.

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关键词

BMI,BF%,FTO,GMDR,GWAS,IRX3,SNP,TC,TG,WC,WHO

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