Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival.

Pär Hallberg,Hans Smedje,Niclas Eriksson,Hugo Kohnke,Makrina Daniilidou,Inger Öhman,Qun-Ying Yue,Marco Cavalli,Claes Wadelius,Patrik K E Magnusson,Anne-Marie Landtblom,Mia Wadelius

EBioMedicine（2019）

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摘要

We found a novel association between Pandemrix-induced narcolepsy and the non-coding RNA gene GDNF-AS1, which has been shown to regulate expression of the essential neurotrophic factor GDNF. Changes in regulation of GDNF have been associated with neurodegenerative diseases. This finding may increase the understanding of disease mechanisms underlying narcolepsy. Associations between Pandemrix-induced narcolepsy and immune-related genes were replicated.

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关键词

(MeSH),Narcolepsy,Influenza vaccines,Influenza A virus,H1N1 subtype,Drug-related side effects and adverse reactions,Genome-wide association study,Pharmacogenetics,Glial cell line-derived neurotrophic factor,RNA, long noncoding,Autoimmune diseases,Genetic variation

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