Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.

Melanie S Patzak,Vijayalakshmi Kari,Shilpa Patil,Feda H Hamdan,Robert G Goetze,Marius Brunner,Jochen Gaedcke,Julia Kitz,Duncan I Jodrell,Frances M Richards,Christian Pilarsky,Robert Gruetzmann,Petra Rümmele,Thomas Knösel,Elisabeth Hessmann,Volker Ellenrieder,Steven A Johnsen,Albrecht Neesse

EBioMedicine（2019）

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摘要

NT5C1A is robustly expressed in tumor cells of resected PDAC patients. Moreover, NT5C1A mediates gemcitabine resistance by decreasing the amount of intracellular dFdCTP, leading to reduced tumor cell apoptosis and larger pancreatic tumors in mice. Further studies should clarify the role of NT5C1A as novel predictor for gemcitabine treatment response in patients with PDAC.

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关键词

Cytosolic 5′-nucleotidase 1A,Chemotherapeutic resistance,Gemcitabine,Pancreatic cancer

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