Impact Of Moderate To Severe Obstructive Sleep Apnea On The Cognition In Idiopathic Pulmonary Fibrosis

IntroductionIdiopathic pulmonary fibrosis (IPF) is a relentlessly progressive lung disease with a fatal prognosis to whose rapid evolution multiple comorbidities may contribute, one of the most common being obstructive sleep apnea (OSA). There are several potential factors and conditions for the emergence of a cognitive deficit in relation to IPF or associated morbidities.ObjectivesThe goals of this study were to assess cognition in patients with IPF in stable phase and to identify clinical cognition modifiers.MethodsIn a cross-sectional study, 23 patients with IPF were evaluated using Montreal Cognitive Assessment (MoCA), an instrument for detecting mild cognitive impairments and were screened for OSA through overnight cardiorespiratory polygraphy and for anxiety and depression with three specific scale (Generalized Anxiety Disorder 7-item scale: GAD-7; the Patient Health Questionnaire: PHQ-9; Hospital Anxiety and Depression Scale: HADS).ResultsMoCA score was lower in patients with IPF when compared to controls subjects (24 [21,26] vs. 27 [26,28], p = 0.003) but not as significantly as in COPD patients (21 [18.8,23.3], p< 0.0001). OSA was diagnosed in 19 (82.6%) IPF patients, 12 patients showed the presence of moderate-severe forms (63.15%). IPF patients with cognitive impairment (MoCA< 23) exhibit a higher severity of OSA (apneea hypopnea index-AHI: 33.0 +/- 19.1 vs. 12.44 +/- 8.2, p = 0.018), and a higher Epworth score (7.1 +/- 3.3 vs. 4.3 +/- 1.8, p = 0.013). Anxiety and depression scores were not correlated with MoCA results.ConclusionsImpaired cognition in patients with IPF is mild and affect the areas of visuospatial abilities, language and working memory. OSA could be a possible predictor of IPF cognition deficit. Given the high prevalence of multiple types of sleep disorders in IPF patients, these should be investigated at least by cardiorespiratory polygraphy.