Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.

Takaaki Komatsu,Soh Katsuyama,Fumihide Takano, Takemasa Okamura,Chikai Sakurada,Minoru Tsuzuki,Kakuyou Ogawa, Atsuhito Kubota,Osamu Morinaga,Kenji Tabata,Tsukasa Sakurada

Neuroscience Letters（2019）

引用 12|浏览8

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摘要

•Oral administration of sinomenine attenuates formalin-induced nociceptive behavior.•Oral administration of sinomenine inhibits ERK activation induced by intra plantar injection of formalin in spinal cord.•The analgesic effect of sinomenine may be evoked by μ-opioid receptors.

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关键词

Sinomenine,Aninociception,Formalin test,Spinal ERK phosphorylation,μ-opioid receptor

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