Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder.
NEURAL REGENERATION RESEARCH(2019)
摘要
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based morphological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6 +/- 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7 +/- 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-sample t-test and multiple regression analysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyms, insular lobe, cingulate gyms, precuneus, rectus gyms, and superior frontal gyms. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyms, postcentral gyms, posterior cingulate gyms, hippocampus, lingual gyms, middle occipital gyms, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electromyographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyms, precentral gyms, superior frontal gyms, cuneus, inferior parietal lobule, angular gyms, superior parietal gyms, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. These findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients.
更多查看译文
关键词
nerve regeneration,idiopathic rapid eye movement sleep behavior disorder,synucleinopathies,magnetic resonance imaging,gray matter volume,statistic parametric mapping,voxel-based morphometry,structure,Parkinson's disease,neurodegenerative diseases,neural regeneration
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络