Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms.

Chia-Li Wei,Sabrina Wang, Jui-Ting Yen,Yun-Fang Cheng, Chia-Li Liao,Chih-Chieh Hsu,Chien-Chen Wu,Ying-Chieh Tsai

Brain Research（2019）

引用 87|浏览7

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摘要

•Lactobacillus paracasei PS23 reverses corticosterone-induced depressive behaviors.•PS23 improves corticosterone-reduced hippocampal protein levels of MR, GR and BDNF.•Live PS23 reverses corticosterone-reduced 5-HT levels.•Heat-killed PS23 reverses corticosterone-reduced dopamine levels.•PS23 improves fecal microflora in corticosterone-treated mice.

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关键词

Psychobiotics,Depression,Gut–brain axis,Corticosterone,Mice,Fluoxetine

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