Inhibiting neuraminidase can make the difference.

Immunogens inducing antibodies against the stem of influenza virus hemagglutinin are promising candidates for the development of universal vaccines. In this issue of JEM, Kosik et al. (https://doi.org/10.1084/jem.20181624) report that inhibition of neuraminidase by anti-stem antibodies contributes to their broadly neutralizing activity.