Hepatic PPARα is critical in the metabolic adaptation to sepsis
Journal of Hepatology（2019）
摘要
•Sepsis activates hepatic PPARα.•PPARα plays a protective role in sepsis.•Pparα-deficiency impairs FA utilization in the liver during sepsis.•Hepatocyte Pparα-deficiency worsens the outcome of bacterial infection.•PPARα activity is lower in livers of non-surviving critically ill patients.
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关键词
Nuclear receptors,Sepsis,Metabolism,Hepatocytes,Inflammation
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