NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors.

Andrea Wang-Gillam,Richard A Hubner,Jens T Siveke,Daniel D Von Hoff,Bruce Belanger,Floris A de Jong,Beloo Mirakhur,Li-Tzong Chen

European Journal of Cancer（2019）

引用 167|浏览28

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摘要

•Final analysis of NAPOLI-1 trial of liposomal irinotecan confirmed primary analysis.•Longer overall survival in metastatic pancreatic cancer post–first line progression.•Long-term survival linked to higher performance score, younger age and lower CA19-9.•No new safety signals for liposomal irinotecan + 5-fluorouracil/leucovorin regimen.

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关键词

Pancreatic adenocarcinoma,Liposomal irinotecan,Treatment outcome,Long-term survivors,NAPOLI-1

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