Brief Report: Clinical Utility of Cerebrospinal Fluid Cell Free-DNA as Liquid Biopsy for Leptomeningeal Metastases in ALK-Rearranged NSCLC.

Liquid biopsy of CSF is more sensitive than plasma to detect targetable alterations, characterizing resistance mechanisms on progression and monitoring tumor response in ALK-rearranged NSCLC patients with LM. Thus CSF might be promising as a medium of liquid biopsy in LM.