Intra-axonal diffusivity in brain white matter.
NeuroImage(2019)
摘要
Biophysical modeling lies at the core of evaluating tissue cellular structure using diffusion-weighted MRI, albeit with shortcomings. The challenges lie not only in the complexity of the diffusion phenomenon, but also in the need to know the diffusion-specific properties of diverse cellular compartments in vivo. The likelihood function obtained from the commonly acquired Stejskal-Tanner diffusion-weighted MRI data is degenerate with different parameter constellations explaining the signal equally well, thereby hindering an unambiguous parameter estimation.
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关键词
White matter,Diffusion MRI,Diffusion encoding,Planar encoding,Micro-structure imaging,Intra-axonal diffusivity,Orientation dispersion
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