Upregulation of cystathionine-γ-lyase/hydrogen sulfide pathway underlies the celecoxib counteraction of cyclosporine-induced hypertension and renal insult in rats.

•Celecoxib reverses the hypertensive, nephrotoxic, and CSE/H2S inhibitory effects of CSA.•The celecoxib effects are replicated by Na2S and abrogated by DL-PAG”.•Celecoxib or Na2S ameliorates the inflammatory, oxidative, and apoptotic insults of CSA.