Functional and Radiologic Assessment of the Brain after Reduced-Intensity Unrelated Donor Transplantation for Severe Sickle Cell Disease-Blood and Marrow Transplant Clinical Trials Network #0601.

•Brain magnetic resonance imaging was stable in 10 of 13 patients after unrelated hematopoietic cell transplantation (HCT).•Neurocognition stabilized after unrelated HCT for sickle cell disease.•Long-term follow-up of brain imaging and function is essential after HCT.•Secondary outcome evaluations measure the influence of HCT on disease.