The prognostic impact of pretransplant inflammatory and nutritional status in adult patients after myeloablative single cord blood transplantation.

Biology of Blood and Marrow Transplantation(2019)

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摘要
•We retrospectively evaluated the impact of pretransplantation inflammatory and nutritional status, using such measures as the controlling nutritional status (CONUT) score, Prognostic Nutritional Index (PNI), Glasgow Prognostic Score (GPS), and C-reactive protein-albumin ratio (CAR), on survival, as well as nonrelapse mortality, relapse, engraftment, and graft-versus-host disease (GVHD)in 165 adult recipients of myeloablative single cord blood transplantation.•A higher CONUT score, which is indicative of poor inflammatory and nutritional status, was significantly associated with poor outcomes, including low neutrophil engraftment and development of extensive chronic GVHD.•A higher CAR, which is also suggestive of poor inflammatory and nutritional status, was significantly associated with poor neutrophil engraftment and higher overall mortality.•Body mass index was not associated with transplantation outcomes.
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关键词
Cord blood transplantation,Controlling nutritional status,Prognostic nutritional index,Glasgow Prognostic Score,CRP-albumin ratio,Body mass index
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