Dysfunctional ErbB2, an EGF receptor family member, hinders repair of asthmatic airway epithelial cells.

Hideki Inoue, Takeshi Hattori,Xiuxia Zhou, Emily B Etling,Brian D Modena,John B Trudeau,Fernando Holguin,Sally E Wenzel

Journal of Allergy and Clinical Immunology（2019）

引用 16|浏览15

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摘要

These results implicate a primary defect in the ErbB2 pathway as constraining asthmatic epithelial repair processes. Restoration of homeostatic ErbB2 function should be considered as a novel asthma therapeutic target.

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关键词

Asthma,epidermal growth factor receptor,erythroblastosis oncogene B2,epithelial cell,wound repair,airway inflammation,cell proliferation,cyclin D1,air-liquid interface culture

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