Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer.

Gillian Vandekerkhove,Werner J Struss,Matti Annala,Heini M L Kallio,Daniel Khalaf,Evan W Warner,Cameron Herberts,Elie Ritch,Kevin Beja,Yulia Loktionova,Antonio Hurtado-Coll,Ladan Fazli,Alan So,Peter C Black,Matti Nykter,Teuvo Tammela,Kim N Chi,Martin E Gleave,Alexander W Wyatt

European Urology（2019）

引用 134|浏览36

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摘要

Circulating tumor DNA (ctDNA) is highly abundant in de novo metastatic prostate cancer, but short-term androgen deprivation therapy rapidly reduces ctDNA. The best approach for tumor molecular subtyping and precision oncology should utilize both primary tissue biopsy and ctDNA.

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关键词

Circulating tumor DNA,Cell-free DNA,Androgen deprivation therapy,Castration-sensitive,DNA repair,Liquid biopsy,Precision oncology,Sequencing,Tissue biopsy

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