UGT1A1 polymorphisms with irinotecan-induced toxicities and treatment outcome in Asians with Lung Cancer: a meta-analysis

    Xuewei Chen
    Xuewei Chen
    Qiuhua Deng
    Qiuhua Deng
    Minzhang Guo
    Minzhang Guo
    Yang Liu
    Yang Liu
    Qihua He
    Qihua He

    Cancer Chemotherapy and Pharmacology, pp. 1109-1117, 2017.

    Cited by: 4|Bibtex|Views1|Links
    Keywords:
    UGT1A1 polymorphismIrinotecanToxicityTumor responseLung cancerMore(1+)

    Abstract:

    Previous studies of irinotecan pharmacogenetics have shown that the UGT1A1*28 polymorphism has an effect on irinotecan (IRI)-induced toxicities in Caucasians. Yet compared with the UGT1A1*6 mutation, the UGT1A1*28 occurs at a much lower frequency in the Asians. Whether UGT1A1*6 and UGT1A1*28 are associated with IRI-induced neutropenia, di...More

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