Prospective Memory Impairment In Patients With White Matter Lesions

Objective: A vast majority of the episodic memory literature in white matter lesions (WML) had focused on "retrospective memory (RM)", little was known about prospective memory (PM) in WML patients. The aim of our study was to investigate the effect of WML patients on event-based prospective memory (EBPM) and time-based prospective memory (TBPM). In addition, our study attempted to understand the possible mechanisms of PM damage in WML patients. Methods: A total of 42 WML patients and 40 age and education level matched healthy controls were included. EBPM (an action whenever particular words were presented) and TBPM (an action at certain times) were performed to test the involvement of PM in WML. The extent of WML within cholinergic pathways were assessed using the cholinergic pathways hyperintensities scale (CHIPS). Results: A significant difference was found in the performance of Montreal Cognitive Assessment (MOCA) (21.8 +/- 3.9 vs. 26.6 +/- 1.7, p < 0.05) and TBPM (2.88 +/- 1.21 vs. 4.27 +/- 0.78, p < 0.05), but not Mini-Mental State Examination (MMSE) (26.9 +/- 2.8 vs. 27.3 +/- 1.2, p > 0.05) and EBPM (3.62 +/- 1.25 vs.4.47 +/- 1.11, p > 0.05) in WML patients compared with the healthy controls. Moreover, TBPM and MOCA scores were negatively correlated with CHIPS scores. Conclusions: WML patients were impaired in TBPM but not in EBPM, supporting that EBPM and TBPM have different neural mechanisms. Our results demonstrated that WML are involved in the TBPM probably by affecting the central cholinergic pathway.