Could Alzheimer’s Disease Originate in the Periphery and If So How So?
Molecular Neurobiology, pp. 1-29, 2018.
Alzheimer’s diseaseGene expressionInflammationMicrogliaMitochondriaMore(1+)
The classical amyloid cascade model for Alzheimer’s disease (AD) has been challenged by several findings. Here, an alternative molecular neurobiological model is proposed. It is shown that the presence of the APOE ε4 allele, altered miRNA expression and epigenetic dysregulation in the promoter region and exon 1 of TREM2, as well as ANK1 h...More
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