Genetic and structural insights into broad neutralization of hepatitis C virus by human V H 1-69 antibodies

    Science advances, Volume 5, Issue 1, 2019.

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    Abstract:

    An effective vaccine to the antigenically diverse hepatitis C virus (HCV) must target conserved immune epitopes. Here, we investigate cross-neutralization of HCV genotypes by broadly neutralizing antibodies (bNAbs) encoded by the relatively abundant human gene family . We have deciphered the molecular requirements for cross-neutralizati...More

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