Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.

Georgia Minakaki,Fabio Canneva,Frédéric Chevessier, Frederik Bode,Stefanie Menges,Ivanna K Timotius,Liubov S Kalinichenko,Holger Meixner,Christian P Müller,Bjoern M Eskofier,Nicolas Casadei,Olaf Riess,Rolf Schröder,Jürgen Winkler,Wei Xiang,Stephan von Hörsten,Jochen Klucken

Behavioural Brain Research（2019）

引用 27|浏览65

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摘要

•Automated mouse gait assessment sensitively depicts gait pattern alterations.•Alpha-synuclein KO and transgenic mice show gait and postural control deficits.•4 weeks treadmill exercise notably improved gait activity and postural control.•Treadmill exercise improved dopaminergic and alpha-synuclein homeostasis.•Motor and biochemical improvement was not paralleled by cerebral autophagy changes.

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关键词

ALP,aSyn,BAC,CPu,h,hu,IR,KO,Lamp2a,MAP1LC3/LC3,mTOR,p62,PD,R (/noR),RT,TH,vs,WB,WT

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